|
KMID : 0613820130230050682
|
|
Journal of Life Science
2013 Volume.23 No. 5 p.682 ~ p.688
|
|
|
Effect of Fermented Cudrania tricuspidata Fruit Extracts on the Generation of the Cytokines in Mouse Spleen Cells
|
|
Seo Min-Jeong
Kang Byoung-Won
Park Jeong-Uck
Kim Min-Jeong
Lee Hye-Hyeon
Kim Nam-Hee
Kim Kwang-Hyuk
Rhu En-Ju
Jeong Yong-Kee
|
|
|
Abstract
|
|
|
|
We investigated a physiological function by fermenting a medicinal mushroom, (Cudrania tricuspidata fruit). A fermentation using lactic acid bacteria and the extracts isolated from 70% ethanol fractionation was included in cultured mouse spleen cells for cytokine secretion. As a result, total polyphenol content improved by 47% by organic acid fermentation. This was regarded as immune activity in fermented C. tricuspidata fruits, as the levels of interleukin (IL)-2 and IL-4 secretion increased. In addition, when the extracts were treated with a stimulant lipopolysaccharide, the secretion of helper T (Th) 1 cytokines IL-2, IL-12, and tumor necrosis factor-α was suppressed, while the secretion of Th2 cytokines IL-4, IL-5, IL-6, and IL-10 significantly increased. Therefore, this study suggests that fermentative C. tricuspidata fruit extracts can contribute to the suppression of cellular immune reactions induced by the expression of Th1 cells and activation of the expression of Th2 cells inducing humoral immune reactions associated with the antibody generation by B lymphocytes.
|
|
|
KEYWORD
|
|
|
Cudrania tricuspidata, T lymphocyte, cytokine, fermentation, Lactobacillus sp.
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|